The difficult subject of dosage recommendations
Feb 23, 2025
Note: This article provides general information and does not replace medical advice. Please follow the information on the label/product page and consult a healthcare professional about taking these substances if you have a medical condition or take medication.
Every organism is individual, including and especially in its metabolism, ability to absorb particular substances and need for them, so it is impossible to provide dosage recommendations that are appropriate for everyone. Dosage recommendations for dietary supplements, for example those of the World Health Organization, should be treated with great caution because an individual's actual requirements may be many times (!) higher. Safety considerations play the greatest role in the World Health Organization's recommendations: the recommendations are based on whether the dosage is safe. This has to be the case: no one following these recommendations should put themselves at risk by doing so. Consequently, WHO dosage recommendations are decidedly 'conservative'. This is particularly apparent in the disagreement among experts over what dosage of vitamin D3 would be 'reasonable'; a great many experts consider the WHO's vitamin D3 recommendations extremely low.
One possible way to address this problem is to consult a nutritionist or doctor. They can recommend dosages for many substances based on laboratory results.
A possible approach to staying on the safe side if you plan to take several substances: Start with the substance that is most important to you. In my case, this was NMN. Begin with the minimum dosage (this is usually the WHO recommendation, but there is no such recommendation for NMN because NMN has not yet been approved as a dietary supplement). I therefore started with 250 mg NMN. Then take this one substance at this dosage for about 2 weeks. If you tolerate it well, add the next substance at its minimum dosage, again for 2 weeks. If you have an intolerance reaction to any of the substances, this approach will make it easy to identify the substance concerned.
Then take all your chosen substances for about three months and observe how your body responds. Next, increase the dosage gradually! At intervals of one week, increase the dose of each individual substance, then wait for about a month without changing anything. Continue these gradual increases until you reach your chosen final dosage.
I am 75 years old myself. To give you an idea of what final dosages might make sense for you, I am sharing my very personal list of the anti-aging substances I take, at the dosages I have ultimately chosen:
With NMN, you will notice that I take two forms of NMN at the same time. The reason is as follows: these are two different molecules (NMNH is the 'reduced form' of NMN, meaning the molecule lacks an oxygen atom, making it much smaller and allowing it to enter the cell much more easily), and naturally these two molecules go through different stages when metabolized in the body. I simply want to benefit from both possibilities and hope for synergistic effects. Please also see the article on NMNH here in this BLOG.
New additions: magnesium L-threonate, taurine, liposomal vitamin C and liposomal vitamin D3
Here you can see my daily supply: three portions, and in the top plastic container you can see a capsule of UthPeak/NMNH sealed in an aluminum pouch (never buy NMNH as loose powder in a container, as it is not protected from oxygen there; NMNH oxidizes very, very quickly because the molecule lacks an oxygen atom, hence the H in NMNH). Magnesium L-threonate was added to the list shown further up a few months ago. I use the affordable powder that AFEGA sells through the AFEGA Chemicals shop and, for convenience, transfer it into the container shown in the picture. I do the same with taurine: I use the powder we sell and, for convenience, transfer it into the container shown here. I add the powders to the freshly squeezed orange juice at the front of the picture (2 x daily).
If you have further questions, for example about interactions between particular substances and medications you take, please email our colleagues at the AFEGA Research Group)
Ideally, please complete the questionnaire linked below and download the file by clicking the 'Download answers' button. Then send this file with a brief covering message to the AFEGA Research Group (email: research@afega.net): https://www.afega.shop/pages/fragebogen-fur-eine-individuelle-produktempfehlung
